Advantech MIO-5381 3.5-inch Intel Core Ultra

The Advantech MIO-5381 is a 3.5-inch SBC featuring Intel Core Ultra 9/7/5 (Panther Lake) processors with up to 50 TOPS of NPU acceleration and EdgeBMC out-of-band management.

The MIO-5381 scales from the Core Ultra 5 325 to the 16-core Ultra 9 388H at 25W TDP, with dual-channel DDR5-7200 up to 128GB and IBECC support. It drives four independent displays via eDP, dual HDMI and dual USB-C (DP Alt Mode), and offers GbE + 2.5GbE LAN, four COM ports, dual CAN-FD and dual MIPI-CSI. Expansion spans four M.2 slots — E-Key, B-Key with nano SIM and dual M-Key Gen5/Gen4 — plus MCIO PCIe Gen5 x4 on selected SKUs. Standard 0-60°C and extended -40 to 85°C industrial SKUs run from 12-24V DC.

Key features

• Intel Core Ultra 9 388H / 7 358H / 7 356H / 5 325 (Panther Lake)
• Up to 16 cores, 25W TDP
• Integrated NPU up to 50 TOPS
• Dual-channel DDR5-7200 up to 128GB with IBECC
• 4x independent displays: eDP + 2x HDMI + 2x USB-C (DP Alt Mode)
• Intel i210 GbE + i226 2.5GbE
• 2x CAN-FD
• 2x RS-232/422/485, 8-bit GPIO
• 2x MIPI-CSI (C-PHY)
• M.2 E-Key 2230 + B-Key 3052 with nano SIM
• 2x M.2 M-Key 2280 (PCIe Gen5 + Gen4)
• 1x MCIO PCIe Gen5 x4 (selected SKUs)
• TPM 2.0
• 12-24V DC, extended -40 to 85°C industrial SKU

Applications

• Edge AI vision systems
• Industrial automation and control
• Remotely managed edge appliances
• Machine vision
• Compact embedded systems